Michael P. Latham, Ph.D.

 
 

The information below focuses on my professional life.  However, my wife and I have many other interests: hiking, backpacking, mountaineering, skiing and snowshoeing, and traveling.  Since moving to Canada in 2008, we have taken a number of canoe trips in Ontario.  I am also a runner, having finished several half- and full-marathons.  Check out the rest of our website to see some of our great adventures.

 

Publications

  1. 1.A similar in vitro and in cell lysate folding intermediate for the FF domain. J Mol Biol. (2014).

  2. 2.Viscosity-dependent kinetics of protein conformational exchange: microviscosity effects and the need for a small viscogen. J Phys Chem B. (2014) 118:4546-51.

  3. 3.Understanding the mechanism of proteasome 20S core particle gating. Proc Natl Acad Sci USA. (2014) 111: 5532-7.

  4. 4.Phosphorylation releases constraints to domain motion in ERK2. Proc Natl Acad Sci USA. (2014) 111: 256-11.

  5. 5.Probing non-specific interactions of Ca²⁺-calmodulin in E. coli lysate. J Biomol NMR. (2013) 55: 239-47.

  6. 6.Is buffer a good proxy for a crowded cell-like environment? A comparative NMR study of calmodulin side-chain dynamics in buffer and E. coli lysate. PLoS One. (2012) 7: e48226.

  7. 7.NMR chemical exchange as a probe for ligand-binding kinetics in a theophylline-binding RNA aptamer. J Am Chem Soc (2009) 131: 5052-3.

  8. 8.Measurement of imino (1)H-(1)H residual dipolar couplings in RNA. J Biomol NMR. (2009) 43: 121-9.

  9. 9.High-resolution pyrimidine- and ribose-specific 4D HCCH-COSY spectra of RNA using the filter diagonalization method. J Biomol NMR. (2008) 41: 209-19

  10. 10.Comparison of alignment tensors generated for native tRNAval using magnetic fields and liquid crystalline media. J Biomol NMR. (2008) 40: 83-94

  11. 11.Magnetic field induced residual dipolar couplings of imino groups in nucleic acids from measurements at a single magnetic field. J Biomol NMR. (2007) 39: 91-6.

  12. 12.NMR methods for studying the structure and dynamics of RNA. Chembiochem. (2005) 6: 1492-505.

  13. 13.Sequence-specific 1H, 13C and 15N resonance assignments of the N-terminal, 135-residue domain of KaiA, a clock protein from Synechococcus elongatus. J Biomol NMR. (2001) 21: 179-80.



Mailing Address

University of Toronto

Department of Molecular Genetics

NMR Centre, Medical Sciences Building, Room 1233

1 King's College Circle

Toronto, ON, M5S 1A8

Canada

Fellowships

CIHR Training Program in Protein Folding and Interaction Dynamics. Oct. 2011 - Present.

International Research Fellow.  National Science Foundation.  Oct. 2009 - Oct. 2011.

Molecular Biophysics Training Grant. National Institutes of Health/University of Colorado, Boulder.  May 2004 - May 2006.


Education

Post Doctoral Research Fellow

Department of Molecular Genetics, University of Toronto

Advisor: Prof. Lewis E. Kay, FRS

July 2008 - Present


Ph.D.

“Developing Improved Methods for Structural and Dynamics Studies of RNA by NMR Spectroscopy”

Department of Chemistry and Biochemistry, University of Colorado, Boulder

Advisor: Prof. Arthur Pardi

August 2003 - August 2008


B.Sc.

Hampden-Sydney College

August 1995 - May 1999


Miscellaneous Scientific Work Experience

Research Chemist I

Macleod Pharmaceuticals, Inc.

October 2001 - August 2003


Long-Term Substitute Teacher

Mecklenburg County Va Public Schools, Bluestone High School

May 1998 - July 1998